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Jay W Heinecke Selected Research

Hemeproteins (Heme Protein)

7/2010Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export.
8/2004Neuronal expression of myeloperoxidase is increased in Alzheimer's disease.
1/2002Generation of intramolecular and intermolecular sulfenamides, sulfinamides, and sulfonamides by hypochlorous acid: a potential pathway for oxidative cross-linking of low-density lipoprotein by myeloperoxidase.

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Jay W Heinecke Research Topics

Disease

50Atherosclerosis
01/2022 - 01/2002
41Cardiovascular Diseases (Cardiovascular Disease)
10/2020 - 06/2002
33Inflammation (Inflammations)
10/2019 - 05/2002
16Coronary Artery Disease (Coronary Atherosclerosis)
01/2021 - 02/2003
12Insulin Resistance
01/2021 - 07/2005
11Vascular Diseases (Vascular Disease)
08/2015 - 02/2003
7Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2022 - 02/2008
6Hyperglycemia
11/2019 - 01/2004
4Infections
01/2020 - 02/2004
4Acute-Phase Reaction
02/2016 - 03/2007
4Obesity
12/2014 - 05/2009
4Neoplasms (Cancer)
04/2009 - 10/2002
3Dyslipidemias (Dyslipidemia)
11/2021 - 12/2010
3Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2021 - 10/2005
3Diabetes Mellitus
10/2020 - 01/2019
3Hyperlipidemias (Hyperlipidemia)
07/2009 - 12/2004
2Coronary Disease (Coronary Heart Disease)
01/2022 - 01/2019
2Myocardial Infarction
01/2022 - 11/2005
2Hypertriglyceridemia
11/2021 - 07/2008
2Type 2 Diabetes Mellitus (MODY)
10/2020 - 03/2016
2Atherosclerotic Plaque (Atheroma)
12/2019 - 10/2019
2Weight Gain
01/2018 - 05/2009
2Pathologic Processes
09/2014 - 02/2008
2Cystic Fibrosis (Mucoviscidosis)
06/2009 - 03/2008
2Lung Diseases (Lung Disease)
06/2009 - 08/2002
2Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
10/2008 - 11/2007
2Diabetic Angiopathies (Diabetic Angiopathy)
07/2005 - 08/2003
2Hypercholesterolemia
12/2004 - 03/2003
2Neurodegenerative Diseases (Neurodegenerative Disease)
08/2004 - 08/2002
2Carcinogenesis
06/2003 - 06/2003
1Thrombosis (Thrombus)
01/2021
1Stroke (Strokes)
01/2019

Drug/Important Bio-Agent (IBA)

33CholesterolIBA
11/2021 - 12/2004
31HDL LipoproteinsIBA
01/2021 - 08/2004
30Proteins (Proteins, Gene)FDA Link
01/2022 - 08/2002
25Peroxidase (Myeloperoxidase)IBA
01/2016 - 01/2002
15Apolipoprotein A-I (Apolipoprotein A1)IBA
10/2019 - 02/2005
14HDL CholesterolIBA
01/2021 - 06/2005
13Lipoproteins (Lipoprotein)IBA
11/2021 - 02/2004
12EnzymesIBA
01/2020 - 08/2004
12Oxidants (Oxidizing Agents)IBA
10/2013 - 08/2002
10oxidized low density lipoproteinIBA
01/2022 - 01/2002
9Triglycerides (Triacylglycerol)IBA
01/2022 - 07/2008
9ApolipoproteinsIBA
01/2021 - 03/2005
9LipidsIBA
12/2010 - 01/2004
6ProteomeIBA
01/2021 - 04/2009
6Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2019 - 09/2008
63-chlorotyrosineIBA
07/2010 - 08/2004
63-nitrotyrosineIBA
07/2010 - 05/2002
6AntioxidantsIBA
07/2006 - 06/2002
5Complement System Proteins (Complement)IBA
01/2020 - 11/2007
5Matrix Metalloproteinases (MMPs)IBA
02/2008 - 08/2003
4IsotopesIBA
10/2020 - 05/2002
4Glucose (Dextrose)FDA LinkGeneric
01/2018 - 08/2003
4ATP-Binding Cassette Transporters (ABC Transporters)IBA
01/2016 - 08/2004
4LDL Receptors (LDL Receptor)IBA
03/2011 - 12/2004
4LDL Lipoproteins (beta Lipoproteins)IBA
03/2010 - 02/2003
4DNA (Deoxyribonucleic Acid)IBA
02/2006 - 10/2002
3Niacin (Nicotinic Acid)FDA LinkGeneric
01/2021 - 09/2008
3Aryldialkylphosphatase (Paraoxonase)IBA
01/2020 - 03/2005
3Insulin (Novolin)FDA Link
11/2019 - 05/2009
3Metalloproteases (Metalloproteinases)IBA
09/2014 - 11/2007
3SterolsIBA
05/2014 - 02/2010
3Serum Amyloid A Protein (Serum Amyloid A)IBA
06/2011 - 03/2005
3Hemeproteins (Heme Protein)IBA
07/2010 - 01/2002
3Amino AcidsFDA Link
06/2006 - 06/2002
3NADPH Oxidases (NAD(P)H oxidase)IBA
08/2005 - 08/2002
3low density lipoprotein inhibitorIBA
03/2005 - 06/2002
2Apolipoproteins B (ApoB)IBA
01/2021 - 02/2016
2Biomarkers (Surrogate Marker)IBA
01/2020 - 08/2007
2Rosiglitazone (Avandia)FDA Link
03/2016 - 02/2010
2Peptide Hydrolases (Proteases)FDA Link
02/2016 - 12/2012
2CarbohydratesIBA
01/2016 - 03/2011
2Messenger RNA (mRNA)IBA
09/2014 - 07/2009
2Nitric Oxide (Nitrogen Monoxide)FDA Link
09/2014 - 10/2004
2Tyrosine (L-Tyrosine)FDA Link
05/2014 - 10/2011
2Peptides (Polypeptides)IBA
10/2013 - 11/2007
2AndrogensIBA
07/2012 - 04/2012
2Acute-Phase Proteins (Acute-Phase Protein)IBA
06/2011 - 03/2005
2ClusterinIBA
12/2010 - 08/2010
2Apolipoproteins E (ApoE)IBA
07/2009 - 03/2007
2Biological ProductsIBA
06/2009 - 02/2005
2Protease Inhibitors (Protease Inhibitor)IBA
04/2009 - 11/2007
2Hypochlorous Acid (Hypochlorite)IBA
11/2007 - 08/2003
2C-Reactive ProteinIBA
06/2006 - 03/2005
2Vitamin EFDA LinkGeneric
04/2006 - 03/2003
25-chlorouracilIBA
02/2006 - 06/2003
2Acrolein (Aqualin)IBA
10/2005 - 06/2005
2Advanced Glycation End ProductsIBA
07/2005 - 08/2003
1Pulmonary Surfactants (Pulmonary Surfactant)IBA
01/2022
1IgA receptor (protein B)IBA
01/2022
1Transcription Factors (Transcription Factor)IBA
11/2021
1Retinol-Binding Proteins (Retinoid Binding Proteins)IBA
01/2021
1CalciumIBA
01/2021
1cytidylyl-(3'-5')-cytidine (CpC)IBA
01/2021
1SerpinsIBA
10/2020
1Antisense OligonucleotidesIBA
11/2019

Therapy/Procedure

7Therapeutics
03/2016 - 02/2003
2Ligation
11/2005 - 05/2002
1Coronary Artery Bypass (Coronary Artery Bypass Surgery)
01/2022